18 November 2005
Science: Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer [clip]
Article includes Mark Rubin....
1: Science. 2005 Oct 28;310(5748):644-8.
Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate
Tomlins SA, Rhodes DR, Perner S, Dhanasekaran SM, Mehra R, Sun XW, Varambally S,
Cao X, Tchinda J, Kuefer R, Lee C, Montie JE, Shah RB, Pienta KJ, Rubin MA,
Recurrent chromosomal rearrangements have not been well characterized in common
carcinomas. We used a bioinformatics approach to discover candidate oncogenic
chromosomal aberrations on the basis of outlier gene expression. Two ETS
transcription factors, ERG and ETV1, were identified as outliers in prostate
cancer. We identified recurrent gene fusions of the 5' untranslated region of
TMPRSS2 to ERG or ETV1 in prostate cancer tissues with outlier expression....